Nobuyuki Okamura Selected Research

alpha-Synuclein

6/2023	Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.
6/2010	In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.
9/2009	In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.

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Nobuyuki Okamura Research Topics

Disease

70	Alzheimer Disease (Alzheimer's Disease) 12/2023 - 11/2002
25	Cognitive Dysfunction 10/2022 - 03/2002
20	Dementia (Dementias) 10/2022 - 07/2009
18	Amyloid Plaque 08/2023 - 01/2004
16	Gliosis 12/2023 - 01/2018
9	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 01/2022 - 01/2017
8	Parkinson Disease (Parkinson's Disease) 06/2023 - 09/2009
7	Neurodegenerative Diseases (Neurodegenerative Disease) 12/2023 - 11/2009
7	Tauopathies 01/2021 - 09/2013
6	Disease Progression 12/2018 - 06/2014
4	Corticobasal Degeneration 01/2021 - 09/2013
4	Atrophy 01/2019 - 05/2014
4	Constipation 01/2019 - 01/2011
4	Proteostasis Deficiencies 01/2018 - 11/2009
3	Multiple System Atrophy 01/2022 - 06/2010
3	Parkinsonian Disorders (Parkinsonism) 01/2019 - 05/2004
3	Sleepiness 01/2019 - 03/2002
2	Neuroinflammatory Diseases 01/2023 - 08/2022
2	Primary Progressive Aphasia 09/2018 - 01/2018
2	Frontotemporal Dementia (Semantic Dementia) 01/2018 - 05/2014
2	Normal Pressure Hydrocephalus 01/2018 - 09/2015
2	Body Weight (Weight, Body) 03/2017 - 12/2002
2	Amyloidosis 01/2012 - 05/2010
1	Cerebral Amyloid Angiopathy (Congophilic Angiopathy) 01/2024
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2024
1	Brain Diseases (Brain Disorder) 01/2023
1	Pathologic Processes 01/2023
1	Lewy Body Disease (Lewy Body Dementia) 01/2023
1	Chronic Renal Insufficiency 01/2021
1	Stroke (Strokes) 10/2020
1	Cerebellar Ataxia (Dysmetria) 01/2019
1	Prodromal Symptoms 01/2019
1	REM Sleep Behavior Disorder 01/2019
1	Inflammation (Inflammations) 12/2018
1	Primary Progressive Nonfluent Aphasia (Progressive Nonfluent Aphasia) 01/2018
1	Movement Disorders (Movement Disorder) 01/2017
1	Dysbiosis 01/2016

Drug/Important Bio-Agent (IBA)

46	Amyloid (Amyloid Fibrils)IBA 01/2024 - 01/2004
24	THK5351IBA 08/2022 - 02/2016
15	Monoamine Oxidase (MAO)IBA 12/2023 - 01/2018
15	Biomarkers (Surrogate Marker)IBA 10/2022 - 11/2002
10	Proteins (Proteins, Gene)FDA Link 01/2023 - 11/2009
10	tau Proteins (tau Protein)IBA 01/2021 - 11/2005
7	Amyloid beta-PeptidesIBA 03/2022 - 01/2004
7	Donepezil (Aricept)FDA LinkGeneric 03/2016 - 03/2006
7	BenzoxazolesIBA 11/2014 - 03/2004
7	2- (2- (2- dimethylaminothiazol- 5- yl)ethenyl)- 6- (2- (fluoro)ethoxy)benzoxazoleIBA 08/2013 - 04/2007
5	daiokanzotoIBA 01/2019 - 01/2011
5	LigandsIBA 01/2017 - 11/2009
4	2- (4'- (methylamino)phenyl)- 6- hydroxybenzothiazole (Pittsburgh compound B)IBA 01/2019 - 09/2013
4	Histamine Antagonists (Antihistamines)IBA 01/2019 - 12/2010
4	Histamine (Histamine Dihydrochloride)FDA Link 01/2010 - 03/2006
3	alpha-SynucleinIBA 06/2023 - 09/2009
3	quinolineIBA 10/2022 - 11/2005
3	SynucleinsIBA 01/2019 - 11/2009
3	2- (4- aminophenyl)- 6- (2- fluoroethoxy)quinolineIBA 05/2014 - 04/2011
2	5- (6- hydroxy- 4- oxo- 2- thioxo- 1,2,3,4- tetrahydroxy- 5- pyrimidinyl)- 2,4- pentadienylidene- 2- thioxodihydro- 4,6(1H,5H)- pyrimidinedioneIBA 08/2023 - 01/2011
2	Protein AggregatesIBA 08/2023 - 01/2018
2	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2023 - 01/2018
2	Loratadine (Alavert)FDA Link 01/2019 - 03/2011
2	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018 - 08/2013
2	Glucose (Dextrose)FDA LinkGeneric 11/2017 - 12/2002
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2017 - 12/2002
2	Cholinesterase Inhibitors (Anticholinesterases)IBA 03/2016 - 01/2012
2	Sennosides (Senokot)IBA 01/2016 - 01/2011
2	benzimidazoleIBA 02/2014 - 11/2005
2	AD 20 (AD-20)IBA 01/2012 - 07/2011
2	Cholinergic Agents (Cholinergics)IBA 01/2012 - 04/2008
2	florbenazine F 18IBA 01/2012 - 07/2011
2	Hypnotics and Sedatives (Sedatives)IBA 07/2011 - 12/2010
2	Vesicular Monoamine Transport Proteins (Vesicular Monoamine Transporter)IBA 07/2011 - 02/2010
2	Chlorpheniramine (Chlorphenamine)FDA LinkGeneric 03/2011 - 03/2002
2	Prion ProteinsIBA 05/2010 - 11/2009
2	6- (2- fluoroethoxy)- 2- (2- (4- methylaminophenil)ethenyl)benzoxazoleIBA 03/2007 - 03/2004
1	2- (4,5- dihydro- 1H- imidazol- 2- yl)- 1- methyl- 1H- indoleIBA 12/2023
1	DeuteriumIBA 12/2023
1	Selegiline (E250)FDA LinkGeneric 12/2023
1	IronIBA 06/2023
1	Glial Fibrillary Acidic ProteinIBA 01/2023
1	LipopolysaccharidesIBA 01/2023
1	ApolipoproteinsIBA 01/2023
1	Peptides (Polypeptides)IBA 01/2023
1	Apolipoproteins E (ApoE)IBA 01/2023
1	IndicanIBA 01/2021
1	EnzymesIBA 01/2021
1	indoleIBA 01/2021
1	LaxativesIBA 01/2019
1	desloratadine (Aerius)FDA LinkGeneric 01/2019
1	CopperIBA 01/2018
1	Polyvinyl Chloride (PVC)IBA 01/2018
1	MetalsIBA 01/2018
1	IonsIBA 01/2018
1	Protein Isoforms (Isoforms)IBA 01/2018
1	ZincIBA 01/2018
1	6- ((3- fluoro- 2- hydroxy)propoxy)- 2- (4- methylaminophenyl)quinolineIBA 01/2017
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2016
1	GlucosidasesIBA 01/2016

Therapy/Procedure

9	Therapeutics 08/2023 - 01/2004
3	Intravenous Administration 08/2023 - 01/2011
2	Kampo Medicine (Kampo) 01/2011 - 01/2011